Mathematica not only fits into standard accessibility frameworks, but also provides its own highly flexible interface accessibility options.
Magnification — change overall notebook magnification
ScriptSizeMultipliers — control size reduction for subscripts, etc.
ScriptMinSize — specify minimum sizes for subscripts, etc.
ImageSize — control image sizes for graphics, etc.
ImageSizeAction — specify how images should automatically be resized
— change syntax coloring schemes
Speak — speak any
Mathematica expression, including math, graphics, etc.
SpokenString — give the text for a spoken representation of an expression
— menu item to speak the current selection
Left-Handed Mouse Configuration
Shift+Delete,
Ctrl+Insert,
Shift+Insert — cut, copy, paste
