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Notebook Shortcuts
Mathematica's interface is carefully optimized for both menu and keyboard use—with many convenient ergonomic features, including some that are not immediately visible from menus.
Reference
Typing Shortcuts »
Multiple Click — select larger and larger subexpressions
Alt+], Alt+}, Alt+) — enter matched brackets: 
, 
, 
Ctrl+L — copy down an input line (Insert ► Input from Above)
Ctrl+Shift+L — copy down an output line (Insert ► Output from Above)
F1 — search for help on the name selected, or to the left
Shift+F1 — bring up a new instance of the help viewer
Shift+Ctrl+Enter — evaluate the selection in place
Shift+Ctrl+C — copy as plain text
Shift+Ctrl+P — print selection
Cell Groups
Ctrl+' — toggle cell groups open/closed
Shift+Ctrl+{, Shift+Ctrl+} — open/close all cell groups
Complete Notebooks
Shift+Close — immediately close a notebook without saving
File ► New — create a new notebook, package, slide show, etc.
