A model of insulin receptor and insulin receptor substrate 1 phosphorylation (Brännmark et al., 2010)
Package with custom reactions
Main model of the example
Insulin Signaling in Human Adipocytes
This example is a slightly modified version of the final model presented in C. Brännmark, R. Palmér, S. T. Glad, G. Cedersund, and P. Strålfors, "Mass and Information Feedbacks through Receptor Endocytosis Govern Insulin Signaling as Revealed Using a Parameter-Free Modeling Framework," Journal of Biological Chemistry, 285(26), 2010 pp.
See the MainModel model for more documentation and simulation results.