WOLFRAM SYSTEM MODELER
Placeholder for the Chromatography example model, available on the Wolfram SystemModeler website.
This is a placeholder model. It requires the BioChem library.
The following documentation is taken from the main example of the downloadable model. Once you have downloaded all the model dependencies, the model can be downloaded here.
This model studies the inner workings of a chromatography column that can be used to separate different chemicals, based on properties such as size and charge.
In order to get the full experience of this example, you need the following:
These pages show an overview of the example. For the full example, open the accompanying notebook Chromatography.nb.
A chromatography column can be used to separate chemicals in order to purify them in large quantities. Separation on smaller analyte volumes is also performed to detect and quantify the constituent parts of a chemical solution.
The column can be divided into a liquid—or mobile—and a solid—or stationary—phase. The liquid phase contains the analytes that are to be separated. The analytes interact with the solid phase in the column, which retains the particles and influences their flow rate. This can be modeled as an equilibrium for the analytes, where they move from the liquid phase to being fixed inside the solid phase. This model assumes noncompetitive binding and linear equilibrium for all the analytes. The effluent is analyzed using a spectrophotometer.
To simulate the model, perform this step:
A preferred stored plot will automatically be displayed when the simulation has finished. This plot can be seen below. If you would like to plot the simulation results for yourself, follow these steps:
To add a secondary plot and plot the spectrophotometer response, perform the following steps:
You can also change the theme of the plot by clicking the Plot Theme button . Select a theme that fills the area under the plot.
You should now see the following graphs
In the notebook that was downloaded together with this model you can find further analyses connected with this model.
This domain example is an informational resource made freely available by Wolfram Research.
A summary of the licensing terms can be found at:
The full legal code can be found at: