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BioSequenceModify[seq,"mod"]

给出将修饰 "mod" 应用于序列 seq 的结果.

BioSequenceModify[seq,{"mod",params}]

为 "mod" 指定参数 params.

BioSequenceModify[modspec]

表示可以应用于生物分子序列的 BioSequenceModify 运算符形式.

更多信息
Details and Options Details and Options
范例  
基本范例  
范围  
"AddBond"  
"AddToCollection"  
Show More Show More
"CanonicalRepresentation"  
"DeleteBond"  
"DropToStartCodon"  
"InnermostBondRepresentation"  
"MakeCircular"  
"MakeLinear"  
"OutermostBondRepresentation"  
"SplitDisconnectedCollection"  
应用  
可能存在的问题  
巧妙范例  
参见
相关指南
历史
按以下格式引用：

BioSequenceModify

BioSequenceModify[seq,"mod"]

给出将修饰 "mod" 应用于序列 seq 的结果.

BioSequenceModify[seq,{"mod",params}]

为 "mod" 指定参数 params.

BioSequenceModify[modspec]

表示可以应用于生物分子序列的 BioSequenceModify 运算符形式.

更多信息

  • 对键进行变形：
  • {"AddBond",{i1,i2}}在 i1 和 i2 处的字母之间添加高阶键
    {"AddBond",Bond[{i1,i2},"type"]}在给定索引之间添加给定类型的键
    {"DeleteBond",{i1,i2}}删除给定索引之间的所有高阶键
    {"DeleteBond",Bond[{i1,i2},"type"]}删除给定索引之间的指定键
  • 循环调整变形：
  • "MakeCircular"将线性序列转换为循环序列
    "MakeLinear"将循环序列转换为线性序列
    {"MakeLinear",i}从第 i 个位置开始转换为线性序列
  • 集合变形：
  • {"AddToCollection",{seq1,seq2,…}}将序列列表合并到序列集合中
    "SplitDisconnectedCollection"将未键合簇分离成不同的集合
  • 仅表示变形：
  • "InnermostBondRepresentation"表示最内层适用序列的键
    "OutermostBondRepresentation"表示最外层序列的键
    "CanonicalRepresentation"将所有序列和键转换为规范形式
  • 翻译变形：
  • "DropIncompleteCodons"从 DNA 或 RNA 的末尾删除不完整的密码子
    "DropToStartCodon"从 DNA 或 RNA 中删除字母直到找到了起始密码子
    "DropFromStopLetter"在找到了停止字母后开始从肽中删除字母

范例

打开所有单元 关闭所有单元

基本范例  (5)

将键添加到序列：

Wolfram Language code: BioSequenceModify[ BioSequence["RNA", "AGGGU"], {"AddBond", Bond[{1, 5}, "MultiHydrogen"]} ]

从序列中删除一个键：

Wolfram Language code: BioSequenceModify[ BioSequence["RNA", "AGGGU", {Bond[{1, 5}, "MultiHydrogen"]}], {"DeleteBond", Bond[{1, 5}, "MultiHydrogen"]} ]

代表最内层序列的所有键，包括所有字母：

Wolfram Language code: BioSequenceModify[ BioSequence["HybridStrand", {BioSequence["DNA", "CAGT"], BioSequence["RNA", "GUA"]}, {Bond[{{1, 2}, {1, 4}}, "MultiHydrogen"]} ], "InnermostBondRepresentation" ]//InputForm

代表最外层序列的所有键：

Wolfram Language code: BioSequenceModify[ BioSequence["HybridStrand", {BioSequence["DNA", "CAGT", {Bond[{2, 4}, "MultiHydrogen"]}], BioSequence["RNA", "GUA", {}]}, {}], "OutermostBondRepresentation" ]//InputForm

将键和序列的表示规范化为排序和简化的形式：

Wolfram Language code: BioSequenceModify[ BioSequence[{BioSequence["DNA", "GGGG"], BioSequence["DNA", "CCCC"]}, {Bond[{{1, 1}, {2, 2}}, "MultiHydrogen"]} ], "CanonicalRepresentation" ]//InputForm

范围  (30)

将线性序列转换为循环序列：

Wolfram Language code: BioSequenceModify[ BioSequence["DNA", "TGGACTTTC", {}], "MakeCircular" ]

将循环序列转换为线性序列：

Wolfram Language code: BioSequenceModify[ BioSequence["CircularDNA", "TGGACTTTC", {}], "MakeLinear" ]

将序列列表添加到序列集合中：

Wolfram Language code: BioSequenceModify[ BioSequence[ {BioSequence["RNA", "AUU"], BioSequence["DNA", "GGC"]} ], {"AddToCollection", {BioSequence["RNA", "GCA"], BioSequence["DNA", "TTC"]}} ]

将序列集合的未键合项分成单独的集合：

Wolfram Language code: BioSequenceModify[ BioSequence[ {BioSequence["HybridStrand", {"CAGT", "GUA"}], BioSequence["DNA", "GGC"], BioSequence["HybridStrand", {"CAU", "ATTCG"}]}, Bond[{{1, 2, 1}, {3, 1, 1}}, "MultiHydrogen"] ], "SplitDisconnectedCollection" ]

在核苷酸末尾删除字母，这样只有完整的密码子才会被拿去翻译：

Wolfram Language code: BioSequenceModify[BioSequence["DNA", "ACTGATATAC"], "DropIncompleteCodons"]

在默认基因翻译表中，删除字母至多到一个起始密码子：

Wolfram Language code: BioSequenceModify[BioSequence["DNA", "ACTGATATAC"], "DropToStartCodon"]

在肽序列中的停止字母之后开始删除项：

Wolfram Language code: BioSequenceModify[BioSequence["Peptide", "MGLSDGEWQ.LVLNVWG"], "DropFromStopLetter"]

"AddBond"  (4)

插入键不需要指定键类型. 如果没有给出，则会进行推断：

Wolfram Language code: BioSequenceModify[ BioSequence["RNA", "GAGGUGG"], {"AddBond", {2, 5}} ]//InputForm
Wolfram Language code: BioSequencePlot[%]

推断的键类型可能取决于被链接的字母：

Wolfram Language code: BioSequenceModify[ BioSequence["Peptide", "CGGGU"], {"AddBond", {1, 5}} ]//InputForm
Wolfram Language code: BioSequenceModify[ BioSequence["Peptide", "DGGGK"], {"AddBond", {1, 5}}]//InputForm

可以将键添加到混合链中：

Wolfram Language code: BioSequenceModify[ BioSequence["HybridStrand", {BioSequence["RNA", "GAGG"], BioSequence["DNA", "GTGG"]}], {"AddBond", {{1, 2}, {2, 2}}} ]
Wolfram Language code: BioSequencePlot[%]

可以将键添加到序列集合中：

Wolfram Language code: BioSequenceModify[ BioSequence[{BioSequence["RNA", "GAGG"], BioSequence["DNA", "GTGG"]}], {"AddBond", {{1, 2}, {2, 2}}} ]
Wolfram Language code: BioSequencePlot[%]

"AddToCollection"  (3)

也可以将单个序列添加到集合中：

Wolfram Language code: BioSequenceModify[ BioSequence[ {BioSequence["RNA", "AUU"], BioSequence["DNA", "GGC"]} ], {"AddToCollection", BioSequence["RNA", "GCA"]} ]

单个基序或混合序列成为一个集合：

Wolfram Language code: BioSequenceModify[ BioSequence["RNA", "AUU"] , {"AddToCollection", BioSequence["RNA", "GCA"]} ]

如果有多个序列集合，则会被合并到结果中：

Wolfram Language code: BioSequenceModify[ BioSequence[ {BioSequence["RNA", "AUU"], BioSequence["DNA", "GGC"]} ], {"AddToCollection", BioSequence[{BioSequence["RNA", "GCA"], BioSequence["DNA", "TTC"]}]} ]

"CanonicalRepresentation"  (3)

如果序列相同，标准化将使用链级键进行排序：

Wolfram Language code: BioSequenceModify[ BioSequence[ {BioSequence["DNA", "NNNN", Bond[{2, 4}]], BioSequence["DNA", "NNNN", Bond[{1, 3}]]} ], "CanonicalRepresentation" ]["SequenceBondList"]

如果序列和链级键相同，则标准化将使用序列键进行排序：

Wolfram Language code: BioSequenceModify[ BioSequence[ {BioSequence["DNA", "NNNNNN", Bond[{5, 6}, "MultiHydrogen"]], BioSequence["DNA", "NNNNNN", Bond[{5, 6}, "MultiHydrogen"]]}, {Bond[{{1, 4}, {2, 3}}, "MultiHydrogen"]} ], "CanonicalRepresentation" ]["SequenceBondList"]

除了排序外，单链集合被简化为链，单基序混合链被简化为基序：

Wolfram Language code: BioSequenceModify[ BioSequence[{BioSequence["HybridStrand", {BioSequence["DNA", "CAGT"]}]}, {Bond[{{1, 1, 2}, {1, 1, 4}}, "MultiHydrogen"]} ], "CanonicalRepresentation" ]

"DeleteBond"  (2)

删除两个索引之间的所有高阶键：

Wolfram Language code: BioSequenceModify[ BioSequence["RNA", "AGGGU", {Bond[{1, 5}, "MultiHydrogen"]}], {"DeleteBond", {1, 5}} ]

删除键始终适用于最外层的形式，即 "SequenceBondList" 属性给出的形式：

Wolfram Language code: nestedExample = BioSequence[{BioSequence["HybridStrand", {BioSequence["DNA", "CAGT", Bond[{2, 4}, "MultiHydrogen"]], BioSequence["RNA", "GUA"] } ]}]
Wolfram Language code: nestedExample["SequenceBondList"]
Wolfram Language code: BioSequenceModify[ BioSequence[nestedExample], {"DeleteBond", {{1, 1, 2}, {1, 1, 4}}} ]

"DropToStartCodon"  (3)

任何遗传翻译表实体可用于指定起始密码子：

Wolfram Language code: BioSequenceModify[BioSequence["DNA", "ACTGATATAC"], {"DropToStartCodon", Entity["GeneticTranslationTable", "VertebrateMitochondrial"]}]

特定密码子或密码子列表可用于指定起始密码子：

Wolfram Language code: BioSequenceModify[BioSequence["DNA", "ACTGATATAC"], {"DropToStartCodon", "ATA"}]
Wolfram Language code: BioSequenceModify[BioSequence["DNA", "ACTGATATAC"], {"DropToStartCodon", {"GAT", "ATA"}}]

可在操作符格式中创建修饰：

Wolfram Language code: BioSequence["DNA", "ACTGATATAC"]//BioSequenceModify["DropToStartCodon"]

有进一步说明的修饰也可用于操作符格式中：

Wolfram Language code: BioSequence["DNA", "ACTGATATAC"]//BioSequenceModify[{"DropToStartCodon", Entity["GeneticTranslationTable", "VertebrateMitochondrial"]}]

"InnermostBondRepresentation"  (1)

向内移动键可以将其从多层带入基序：

Wolfram Language code: BioSequenceModify[ BioSequence[{BioSequence["HybridStrand", {BioSequence["DNA", "CAGT"], "U"}], BioSequence["HybridStrand", {BioSequence["RNA", "GUA"], "T"}]}, {Bond[{{1, 1, 2}, {1, 1, 4}}, "MultiHydrogen"]} ], "InnermostBondRepresentation" ]//InputForm

"MakeCircular"  (2)

RNA 序列可以转化为环状 RNA 序列：

Wolfram Language code: BioSequenceModify[ BioSequence["RNA", "UUGUAGUUA", {}], "MakeCircular"]

肽序列可以转化为环状肽序列：

Wolfram Language code: BioSequenceModify[ BioSequence["Peptide", "MESLVPGFNEKTHVQL", {}], "MakeCircular"]

"MakeLinear"  (3)

环状 RNA 序列可以转化为线性 RNA 序列：

Wolfram Language code: BioSequenceModify[ BioSequence["CircularRNA", "UUGUAGUUA", {}], "MakeLinear"]

环状肽序列可以转化为线性肽序列：

Wolfram Language code: BioSequenceModify[ BioSequence["CircularPeptide", "MESLVPGFNEKTHVQL", {}], "MakeLinear"]

从特定位置开始线性序列：

Wolfram Language code: BioSequenceModify[ BioSequence["CircularPeptide", "MESLVPGFNEKTHVQL", {}], {"MakeLinear", 7}]

将环状序列转换为线性序列时，相对键位置被保留：

Wolfram Language code: BioSequenceModify[ BioSequence["CircularPeptide", "MESLVPGFNEKTHVQL", {Bond[{2, 11}]}], {"MakeLinear", 7}]//InputForm

"OutermostBondRepresentation"  (1)

向内移动键会将它们从任何基序或链的内部带到最外层的序列结构：

Wolfram Language code: BioSequenceModify[ BioSequence[{BioSequence["HybridStrand", {BioSequence["DNA", "CAGT", Bond[{2, 4}, "MultiHydrogen"]], BioSequence["RNA", "GUA"] } ]}], "OutermostBondRepresentation" ]//InputForm

"SplitDisconnectedCollection"  (1)

拆分连接会导致根据新的集合组成重新对键进行编号：

Wolfram Language code: (#["SequenceBondList"])& /@ BioSequenceModify[BioSequence[{BioSequence["DNA", "A"], BioSequence["RNA", "C"], BioSequence["DNA", "G"], BioSequence["DNA", "T"]}, {Bond[{{1, 1}, {4, 1}}], Bond[{{2, 1}, {3, 1}}]}], "SplitDisconnectedCollection"]

应用  (1)

一个环形肽：

Wolfram Language code: circ = BioSequence["CircularPeptide", "QTGGSFFEPFNSYNSGTWEKADGYSNGGVFNCTWRANNVNFTNDGKLKLGLTSSAYNKFDCAEYRST\ NIYGYGLYEVSMKPAKNTGIVSSFFTYTGPAHGTQWDEIDIEFLGKDTTKVQFNYYTNGVGGHEKVISLGFDASKGFHTYAFDWQPGYIKWYVDGVLKH\ TATANIPSTPGKIMMNLWNGTGVDDWLGSYNGANPLYAEYDWVKYTSN", {}];

各种多肽可以通过环形变异而相互关联：

Wolfram Language code: BioSequenceModify[circ, "MakeLinear"]
Wolfram Language code: % === BioSequence[First[Import["https://www.rcsb.org/fasta/entry/2AYH", "FASTA"]]]
Wolfram Language code: BioSequenceModify[circ, {"MakeLinear", 84}]
Wolfram Language code: % === BioSequence[First[Import["https://www.rcsb.org/fasta/entry/1AJK", "FASTA"]]]
Wolfram Language code: BioSequenceModify[circ, {"MakeLinear", 127}]
Wolfram Language code: % === BioSequence[First[Import["https://www.rcsb.org/fasta/entry/1AJO", "FASTA"]]]

可能存在的问题  (2)

给定的修饰不一定可以应用于特定序列类型：

Wolfram Language code: BioSequenceModify[BioSequence["DNA", "ACTGATATAC"], "DropFromStopLetter"]

如果无法推断键类型，则添加无类型键：

Wolfram Language code: BioSequenceModify[ BioSequence["Peptide", "DGGGC"], {"AddBond", {1, 5}}]//InputForm

巧妙范例  (1)

将蛋白质前胰岛素原表示为 BioSequence：

Wolfram Language code: preproinsulin = BioSequence["Peptide", "MALWMRLLPLLALLALWGPDPAAAFVNQHLCGSHLVEALYLVCGERGFFYTPKTRREAEDLQVGQVELGGGPGAG\ SLQPLALEGSLQKRGIVEQCCTSICSLYQLENYCN", {}];

去除信号肽序列以制作胰岛素原：

Wolfram Language code: proinsulin = StringDrop[preproinsulin, 24]

添加二硫键并分裂胰岛素原序列以制造胰岛素：

Wolfram Language code: insulin = BioSequenceModify[BioSequence[StringSplit[proinsulin, BioSequence["Peptide", "RREAEDLQVGQVELGGGPGAGSLQPLALEGSLQKR", {}]]], {"AddBond", {Bond[{{2, 1, 6}, {2, 1, 11}}, "DisulfideBridges"], Bond[{{2, 1, 7}, {1, 1, 7}}, "DisulfideBridges"], Bond[{{2, 1, 20}, {1, 1, 19}}, "DisulfideBridges"]} }]
Wolfram Language code: BioSequencePlot[insulin]
Wolfram Research (2020)，BioSequenceModify，Wolfram 语言函数，https://reference.wolfram.com/language/ref/BioSequenceModify.html （更新于 2021 年）.

文本

Wolfram Research (2020)，BioSequenceModify，Wolfram 语言函数，https://reference.wolfram.com/language/ref/BioSequenceModify.html （更新于 2021 年）.

CMS

Wolfram 语言. 2020. "BioSequenceModify." Wolfram 语言与系统参考资料中心. Wolfram Research. 最新版本 2021. https://reference.wolfram.com/language/ref/BioSequenceModify.html.

APA

Wolfram 语言. (2020). BioSequenceModify. Wolfram 语言与系统参考资料中心. 追溯自 https://reference.wolfram.com/language/ref/BioSequenceModify.html 年

BibTeX

@misc{reference.wolfram_2026_biosequencemodify, author="Wolfram Research", title="{BioSequenceModify}", year="2021", howpublished="\url{https://reference.wolfram.com/language/ref/BioSequenceModify.html}", note=[Accessed: 11-August-2026]}

BibLaTeX

@online{reference.wolfram_2026_biosequencemodify, organization={Wolfram Research}, title={BioSequenceModify}, year={2021}, url={https://reference.wolfram.com/language/ref/BioSequenceModify.html}, note=[Accessed: 11-August-2026]}