The model describes the physiological events that occur after a meal by employing quantitative knowledge that has become available in recent years. Model parameters have been fit to the mean data of a large normal subject database that underwent a triple tracer meal protocol, which provided quasi-model-independent estimates of major glucose and insulin fluxes, for example, meal rate of appearance, endogenous glucose production, utilization of glucose, and insulin secretion.

Fig. 1 and 2 shows the predicted plasma concentrations of glucose and insulin respectively, following a meal containing 70g of glucose.


Fig. 1 predicted plasma glucose concentration after a meal containing 70g of glucose.
Fig. 2 predicted plasma insulin concentration after a meal containing 70g of glucose.

References

C. D. Man, R. A. Rizza, and C. Cobelli, "Meal Simulation Model of the Glucose-Insulin System," IEEE Transactions on Biomedical Engineering, 54(10), 2007, pp. 1740-1749. doi:10.1109/TBME.2007.893506

E. Nyman, C. Brännmark, R. Palmér, J. Brugård, F. H. Nyström, P. Strålfors, and G. Cedersund, "A Hierarchical Whole-Body Modeling Approach Elucidates the Link Between in Vitro Insulin Signaling and in Vivo Glucose Homeostasis," Journal of Biological Chemistry, 286(29), 2011, pp. 26028-26041. doi:10.1074/jbc.M110.188987

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