This model descibres the cell division. Below follows an excerpt of the abstract from the paper describing the model by J. J. Tyson (1991).

"The proteins cdc2 and cyclin form a heterodimer (maturation promoting factor) that controls the major events of the cell cycle. A mathematical model for the interactions of cdc2 and cyclin is constructed. Simulation and analysis of the model show that the control system can operate in three modes: as a steady state with high maturation promoting factor activity, as a spontaneous oscillator, or as an excitable switch. We associate the steady state with metaphase arrest in unfertilized eggs, the spontaneous oscillations with rapid division cycles in early embryos, and the excitable switch with growth-controlled division cycles typical of nonembryonic cells."

Fig. 1 show the simulation results and corresponds to Fig. 3(a) in the paper (J. J. Tyson 1991).


Fig. 1 the model predictions for the total cyclin and active MPF relative to total cdc2.

References

John J. Tyson, "Modeling the Cell Division Cycle: cdc2 and Cyclin Interactions," Proceedings of the National Academy of Sciences of the United States of America, 88(16), 1991, pp. 7328-7332 www.pnas.org/content/88/16/7328.full.pdf

mainCompartment	Value: true Type: Boolean Description: Specifies whether the compartment is a main (top-level) compartment. Used in SBML import/export.
initialConcentrationCDC2kp	Value: 0.75 Type: Concentration (mol/l) Description: Initial concentration of substance of cdc2kp
initialConcentrationMPF	Value: 0.25 Type: Concentration (mol/l) Description: Initial concentration of substance of inactive MPF