WOLFRAM SYSTEM MODELER
MainModelMain model of the example |
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Diagram
Wolfram Language
In[1]:=
SystemModel["BioChem.Examples.InsulinSignaling.MainModel"]
Out[1]:=
Information
The model describes phosphorylation of the insulin receptor (IR) and insulin receptor substrate-1 (IRS1) and endocytosis of the receptor in response to various experimental perturbations in primary human adipocytes. Model analysis reveals that receptor endocytosis is necessary for two identified feedback mechanisms involving mass and information transfer, respectively.
Fig. 1 and 2 shows a characteristic overshoot in the amount of phosphorylated IR and IRS1 respectively, in response to insulin stimulation and is the default simulation produced by the model.
Fig. 1 shows the characteristic overshoot in the amount of phosphorylated insulin receptor (IRiP) in response to insulin stimulation.
Fig. 2 shows the characteristic overshoot in the amount of phosphorylated insulin receptor substrate-1 (IRS1P) in response to insulin stimulation.
Fig. 1 and 2 shows a characteristic overshoot in the amount of phosphorylated IR and IRS1 respectively, in response to insulin stimulation and is the default simulation produced by the model.
Fig. 1 shows the characteristic overshoot in the amount of phosphorylated insulin receptor (IRiP) in response to insulin stimulation.
Fig. 2 shows the characteristic overshoot in the amount of phosphorylated insulin receptor substrate-1 (IRS1P) in response to insulin stimulation.
References
C. Brännmark, R. Palmér, S. T. Glad, G. Cedersund, and P. Strålfors, "Mass and Information Feedbacks through Receptor Endocytosis Govern Insulin Signaling as Revealed Using a Parameter-Free Modeling Framework," Journal of Biological Chemistry, 285(26), 2010, pp. 20171-20179 doi:10.1074/jbc.M110.106849Parameters (2)
| mainCompartment |
Value: true Type: Boolean Description: Specifies whether the compartment is a main (top-level) compartment. Used in SBML import/export. |
|---|---|
| insulinConcentration |
Value: 100 Type: Real (mol/l) |
Components (21)
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IR |
Type: Substance Description: Insulin receptors |
|---|---|---|
|
IRins |
Type: Substance Description: Insulin bound recepors |
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IRinsP |
Type: Substance Description: Phosphorylated, insulin bound receptors |
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IRP |
Type: Substance Description: Phosphorylated receptors (no insulin) |
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IRiP |
Type: Substance Description: Total amount endocytosed, phosphorylated receptors |
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IRi |
Type: Substance Description: Dephosporylated, endocytosed receptors |
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insulinBindingDissociation |
Type: Uurfa Description: Uni-uni reversible forward activation reaction |
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phosphorylation2 |
Type: Uur Description: Uni-uni reversible reaction |
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endocytosis2 |
Type: Uui Description: Uni-uni irreversible reaction |
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phosphorylation1 |
Type: Uur Description: Uni-uni reversible reaction |
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endocytosis1 |
Type: Uui Description: Uni-uni irreversible reaction |
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recycling |
Type: Uui Description: Uni-uni irreversible reaction |
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IRS1 |
Type: Substance Description: Phosphorylated insulin receptor substrate 1 |
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IRS1P |
Type: Substance Description: Insulin receptor substrate 1 |
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dephosphorylation2 |
Type: Uuifa Description: Uni-uni irreversible forward activation reaction |
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IRS1reaction |
Type: IRS1dynamics Description: Reaction describing the dynamics of IRS1 |
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XA |
Type: Substance Description: Activated X |
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X |
Type: Substance Description: Unspecified substance X |
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dephosphorylation1 |
Type: Uui Description: Uni-uni irreversible reaction |
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Xreaction |
Type: Uurfa Description: Uni-uni reversible forward activation reaction |
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Insulin |
Type: SignalSubstance Description: Substance with a concentration not determined by reactions, but by external equations |