WOLFRAM SYSTEM MODELER

MainModel

Main model of the example

Diagram

Wolfram Language

In[1]:=
SystemModel["BioChem.Examples.InsulinSignaling.MainModel"]
Out[1]:=

Information

The model describes phosphorylation of the insulin receptor (IR) and insulin receptor substrate-1 (IRS1) and endocytosis of the receptor in response to various experimental perturbations in primary human adipocytes. Model analysis reveals that receptor endocytosis is necessary for two identified feedback mechanisms involving mass and information transfer, respectively.

Fig. 1 and 2 shows a characteristic overshoot in the amount of phosphorylated IR and IRS1 respectively, in response to insulin stimulation and is the default simulation produced by the model.


Fig. 1 shows the characteristic overshoot in the amount of phosphorylated insulin receptor (IRiP) in response to insulin stimulation.
Fig. 2 shows the characteristic overshoot in the amount of phosphorylated insulin receptor substrate-1 (IRS1P) in response to insulin stimulation.

References

C. Brännmark, R. Palmér, S. T. Glad, G. Cedersund, and P. Strålfors, "Mass and Information Feedbacks through Receptor Endocytosis Govern Insulin Signaling as Revealed Using a Parameter-Free Modeling Framework," Journal of Biological Chemistry, 285(26), 2010, pp. 20171-20179 doi:10.1074/jbc.M110.106849

Parameters (2)

mainCompartment

Value: true

Type: Boolean

Description: Specifies whether the compartment is a main (top-level) compartment. Used in SBML import/export.

insulinConcentration

Value: 100

Type: Real (mol/l)

Components (21)

IR

Type: Substance

Description: Insulin receptors

IRins

Type: Substance

Description: Insulin bound recepors

IRinsP

Type: Substance

Description: Phosphorylated, insulin bound receptors

IRP

Type: Substance

Description: Phosphorylated receptors (no insulin)

IRiP

Type: Substance

Description: Total amount endocytosed, phosphorylated receptors

IRi

Type: Substance

Description: Dephosporylated, endocytosed receptors

insulinBindingDissociation

Type: Uurfa

phosphorylation2

Type: Uur

endocytosis2

Type: Uui

phosphorylation1

Type: Uur

endocytosis1

Type: Uui

recycling

Type: Uui

IRS1

Type: Substance

Description: Phosphorylated insulin receptor substrate 1

IRS1P

Type: Substance

Description: Insulin receptor substrate 1

dephosphorylation2

Type: Uuifa

IRS1reaction

Type: IRS1dynamics

XA

Type: Substance

Description: Activated X

X

Type: Substance

Description: Unspecified substance X

dephosphorylation1

Type: Uui

Xreaction

Type: Uurfa

Insulin

Type: SignalSubstance