The model describes phosphorylation of the insulin receptor (IR) and insulin receptor substrate-1 (IRS1) and endocytosis of the receptor in response to various experimental perturbations in primary human adipocytes. Model analysis reveals that receptor endocytosis is necessary for two identified feedback mechanisms involving mass and information transfer, respectively.

Fig. 1 and 2 shows a characteristic overshoot in the amount of phosphorylated IR and IRS1 respectively, in response to insulin stimulation and is the default simulation produced by the model.


Fig. 1 shows the characteristic overshoot in the amount of phosphorylated insulin receptor (IRiP) in response to insulin stimulation.
Fig. 2 shows the characteristic overshoot in the amount of phosphorylated insulin receptor substrate-1 (IRS1P) in response to insulin stimulation.

References

C. Brännmark, R. Palmér, S. T. Glad, G. Cedersund, and P. Strålfors, "Mass and Information Feedbacks through Receptor Endocytosis Govern Insulin Signaling as Revealed Using a Parameter-Free Modeling Framework," Journal of Biological Chemistry, 285(26), 2010, pp. 20171-20179 doi:10.1074/jbc.M110.106849

mainCompartment	Value: true Type: Boolean Description: Specifies whether the compartment is a main (top-level) compartment. Used in SBML import/export.
insulinConcentration	Value: 100 Type: Real (mol/l)